Lead-exposed rat hippocampi



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Source page: http://commons.wikimedia.org/wiki/File:Lead-exposed_rat_hippocampi.jpg
Description accompanying text reads, "Representative electron

micrographs of coronal sections of the rat hippocampus are shown.

(A, C, and E) control hippocampus. (B, D and F) lead-exposed

hippocampus in rats at weaning that were treated with 0.2% lead

acetate during the gestational and lactational periods as

described. Abnormal appearance of neurons including irregular

shaped nucleus, swollen mitochondria, often vacuolated with

disrupted cristae, a large quantity of heterochromatin collected

inside the nucleus, demyelination or shrinkage, and denaturation of

the myelin sheath were observed. These findings suggest that

hippocampal ultrastructures were injured by lead exposure during

the early stage of life. Scale bar = 1 ?m. NN: normal nucleus; IN:

irregular nucleus; SM: swollen mitochondria; VM: vacuolated

mitochondria; NM: normal mitochondria; H: heterochromatin; DMS:

denaturation of myelin sheath." (only A and B are used in this

modification of the image).
Date April 2009(2009-04)
Source http://www.jnrbm.com/content/8/1/5 Xu, J; Yan, Hc; Yang,

B; Tong, Ls; Zou, Yx; Tian, Y (Apr 2009). "Effects of lead exposure

on hippocampal metabotropic glutamate receptor subtype 3 and 7 in

developmental rats" (Free full text). Journal of negative results

in biomedicine 8: 5. doi:10.1186/1477-5751-8-5. PMID 19374778. PMC:

2674876. http://www.jnrbm.com/content/8//5.
Author Xu, J; Yan, Hc; Yang, B; Tong, Ls; Zou, Yx; Tian, Y (modified 9/1/09 by user:delldot)
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