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|Description||accompanying text reads, "Representative electron
micrographs of coronal sections of the rat hippocampus are shown.
(A, C, and E) control hippocampus. (B, D and F) lead-exposed
hippocampus in rats at weaning that were treated with 0.2% lead
acetate during the gestational and lactational periods as
described. Abnormal appearance of neurons including irregular
shaped nucleus, swollen mitochondria, often vacuolated with
disrupted cristae, a large quantity of heterochromatin collected
inside the nucleus, demyelination or shrinkage, and denaturation of
the myelin sheath were observed. These findings suggest that
hippocampal ultrastructures were injured by lead exposure during
the early stage of life. Scale bar = 1 ?m. NN: normal nucleus; IN:
irregular nucleus; SM: swollen mitochondria; VM: vacuolated
mitochondria; NM: normal mitochondria; H: heterochromatin; DMS:
denaturation of myelin sheath." (only A and B are used in thismodification of the image).
|Source||http://www.jnrbm.com/content/8/1/5 Xu, J; Yan, Hc; Yang,
B; Tong, Ls; Zou, Yx; Tian, Y (Apr 2009). "Effects of lead exposure
on hippocampal metabotropic glutamate receptor subtype 3 and 7 in
developmental rats" (Free full text). Journal of negative results
in biomedicine 8: 5. doi:10.1186/1477-5751-8-5. PMID 19374778. PMC:2674876. http://www.jnrbm.com/content/8//5.
|Author||Xu, J; Yan, Hc; Yang, B; Tong, Ls; Zou, Yx; Tian, Y (modified 9/1/09 by user:delldot)|
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