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English: A. Schematic initial progression of Lewy body deposits in the first stages of Parkinson's Disease, as proposed by Braak and colleagues. B. Localization of the cluster of significant volume reduction in PD compared with HC. The significant cluster located in the medulla oblongata/pons is superimposed as a red blob on the mean normalized anatomical scan of all participants. The axial and sagital sections are centered on the peak of significance (?1; ?36; ?49).
Image comes from an article by Jubault et al. in PlosOne (2009) using Voxel Based Morphometry which searched for regional atrophy in idiopathic Parkinson's Disease by comparing a group of subjects with the disease and a group of healthy controls.
Citation of the original article: Jubault T, Brambati SM, Degroot C, Kullmann B, Strafella AP, et al. (2009) Regional Brain Stem Atrophy in Idiopathic Parkinson's Disease Detected by Anatomical MRI. PLoS ONE 4(12): e8247. doi:10.1371/journal.pone.0008247DOI of the image: 10.1371/journal.pone.0008247.g001
|Date||10 December 2010|
|Author||Thomas Jubault 1,2*, Simona M. Brambati 1, Clotilde Degroot 1, Benoît Kullmann 1, Antonio P. Strafella 3, Anne-Louise Lafontaine 4, Sylvain Chouinard 5, Oury Monchi1,2 1 Unité de Neuroimagerie Fonctionelle, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada, 2 Département de Radiologie, Université de Montreal, Montreal, Quebec, Canada, 3 Toronto Western Hospital/Research Institute & CAMH-PET Imaging Centre, University of Toronto, Toronto, Ontario, Canada, 4 Movement Disorders Unit, McGill University Health Center, Montreal, Quebec, Canada, 5 Unité des Désordres du Mouvement, Centre hospitalier de l'Université de Montréal, Montreal, Quebec, Canada|
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