Ten daily doses of ethanol exposure reduced neurogenesis in hippocampal dentate gyrus during combined ethanol and LPS treatments



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Source page: http://commons.wikimedia.org/wiki/File:Ten_daily_doses_of_ethanol_exposure_reduced_neurogenesis_in_hippocampal_dentate_gyrus_during_combined_ethanol_and_LPS_treatments.jpg
English: Figure 6. Ten daily doses of ethanol exposure reduced neurogenesis in hippocampal dentate gyrus during combined ethanol and LPS treatments. Male C57BL/6J mice were treated intragastrically with ethanol (5 g/kg, i.g.) for either 1 day or 10 days and injected intraperitoneally (i.p.) with LPS (3 mg/kg, i.p.) 24 hrs after ethanol treatment. Mice were sacrificed 1 hr following saline or LPS administration. Brain sections were fixed and stained with anti-mouse PCNA (a marker for proliferation of neural progenitor cells) and anti-goat doublecortin (a marker for immature or newly born neurons) antibodies. (A) Ethanol (5 g/kg, i.g., 1 day) pre-treated group, LPS did not show a decrease in the number of PCNA and doublecortin-IR cells. (B) Ethanol (5 g/kg, i.g., 10 days) pre-treated mice, LPS significantly decreased PCNA and doublecortin-IR cells, suggesting that 10 daily doses of ethanol inhibits neurogenesis during combined ethanol and LPS treatments. (C) The pictures represent PCNA-IR cells in control (upper panel) and ETOH-LPS treated (lower panel) dentate gyri of the hippocampus. (D) Representative pictures of doublecortin (DCX) immunoreactivity. DCX expression was shown in control brain (upper panel) and ETOH-LPS treated brain (lower panel).
Date 2008(2008)
Source Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment
Author Qin L, He J, Hanes RN, Pluzarev O, Hong JS, Crews FT.
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© 2008 Qin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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