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English: Figure 6. Ten daily doses of ethanol exposure reduced neurogenesis in hippocampal dentate gyrus during combined ethanol and LPS treatments. Male C57BL/6J mice were treated intragastrically with ethanol (5 g/kg, i.g.) for either 1 day or 10 days and injected intraperitoneally (i.p.) with LPS (3 mg/kg, i.p.) 24 hrs after ethanol treatment. Mice were sacrificed 1 hr following saline or LPS administration. Brain sections were fixed and stained with anti-mouse PCNA (a marker for proliferation of neural progenitor cells) and anti-goat doublecortin (a marker for immature or newly born neurons) antibodies. (A) Ethanol (5 g/kg, i.g., 1 day) pre-treated group, LPS did not show a decrease in the number of PCNA and doublecortin-IR cells. (B) Ethanol (5 g/kg, i.g., 10 days) pre-treated mice, LPS significantly decreased PCNA and doublecortin-IR cells, suggesting that 10 daily doses of ethanol inhibits neurogenesis during combined ethanol and LPS treatments. (C) The pictures represent PCNA-IR cells in control (upper panel) and ETOH-LPS treated (lower panel) dentate gyri of the hippocampus. (D) Representative pictures of doublecortin (DCX) immunoreactivity. DCX expression was shown in control brain (upper panel) and ETOH-LPS treated brain (lower panel).
|Source||Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment|
|Author||Qin L, He J, Hanes RN, Pluzarev O, Hong JS, Crews FT.|
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© 2008 Qin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
|This file is licensed under the Creative Commons Attribution 2.0 Generic license.|
Creative Commons Attribution 2.0 Generic
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