Interpretation of the cutoff effect in the frame of lipid hypothesis of general anaesthesia



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English: A) Short hydrocarbon chains are relatively rigid in terms of conformational enthropy and are close to alkanol hydroxyl group (“buoy”) tethered to the interface. This makes short chain alkanols efficient mediators that redistribute lateral stress from membrane interior to its interface. B) This ability decreases in the row of n-alkanols since longer chains are more flexible and are not so tightly tethered to the hydroxyl group. C) Polyhydroxyalkanes 1,6,11,16-hexadecanetetraol and 2,7,12,17-octadecanetetraol exhibit significant anesthetic potency as was predicted by cutoff effect because the length of the hydrocarbon chain between hydroxyl groups is smaller than the cutoff.
Date 20 April 2009(2009-04-20)
Source Own work. Information to create this picture was taken from J. Med. Chem., 2005, 48 (12), pp 4172–4176.
Author Akuznetsova
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