Purine Nucleoside Phosphorylase



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English: Computer-generated Model of Purine Nucleoside Phosphorylase (PNP)
Purine Nucleoside Phosphorylase (PNP) is an important target enzyme for the design of anti-cancer and immunosuppressive drugs. Bacterial PNP, which is slightly different from the human enzyme, is used to synthesize chemotherapeutic agents. Knowledge of the three-dimensional structure of the bacterial PNP molecule is useful in efforts to engineer different types of PNP enzymes, that can be used to produce new chemotherapeutic agents. This picture shows a computer model of bacterial PNP, which looks a lot like a display of colorful ribbons. Principal Investigator was Charles Bugg.
Français : Modèle informatique de la Purine Nucléoside Phosphorylase (PNP)
La PNP est une cible importante pour des molécules actives anticancéreuses ou immunosuppressives. La PNP bactérienne, qui est légèrement différente de l'enzyme humaine, est utilisée pour synthétiser des agents chémothérapeutiques. La connaissance de la structure tridimensionnelle de la PNP bactérienne est utile pour obtenir différentes sortes d'enzymes PNP, pouvant être utilisées pour produire de nouveaux agents chémothérapeutiques. Cette image a été réalisée par une équipe dirigée par Charles Bugg.
Date released 1. Feb. 1987
Source Science Directorate at Marshall Space Flight Center (MSFC) (NASA), MSFC Negative Number: 8772406, Reference Number: P-2757
Author NASA
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English: Computer-generated Model of Purine Nucleoside Phosphorylase (PNP)

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